Lobular Breast Cancer: Histomorphology and Different Concepts of a Special Spectrum of Tumors

Invasive lobular breast cancer (ILC) is the most common special histological type of (BC). This review recapitulates developments in histomorphologic assessment ILC from its beginnings with seminal work Foote and Stewart, which was published 1941, until today. We discuss different concepts their implications. These include (i) BC arising mammary lobules, (ii) growing dissociated cells single files, (iii) defined as a morpho-molecular spectrum tumors distinct molecular characteristics related to impaired cell adhesion. also provides comprehensive overview variants, histomorphology, differential diagnosis. Furthermore, this highlights recent advances have contributed better understanding histomorphology ILC, such role basal lamina component laminin, specificities triple-negative E-cadherin P-cadherin expression switching determinant tubular elements CDH1-deficient ILC. Last but not least, we provide detailed account tumor microenvironment including infiltrating lymphocyte (TIL) levels, are comparatively low compared other BCs, correlate clinical outcome. The clearly reflects biology. In clinic, treatment strategies been established for triple-negative, HER2-positive, ER-positive BC. Treatment specialization patients diagnosed just beginnings. Accordingly, deserves greater attention entity diagnostics, patient care, research.